<p>Alzheimer’s disease: pathogenesis, diagnostics, and therapeutics</p>

Abstract: Currently, 47 million people live with dementia globally, and it is estimated to increase more than threefold (∼131 million) by 2050. Alzheimer’s disease (AD) is one of the major causative factors to induce progressive dementia. AD is a neurodegenerative disease, and its pathogenesis has been attributed to extracellular aggregates of amyloid β (Aβ) plaques and intracellular neurofibrillary tangles made of hyperphosphorylated τ-protein in cortical and limbic areas of the human brain. It is characterized by memory loss and progressive neurocognitive dysfunction. The anomalous processing of APP by β-secretases and γ-secretases leads to production of Aβ 40 and Aβ 42 monomers, which further oligomerize…

• FD
  Florida Department of Health

  Award: 8AZ04
• FI
  Florida International University
• UG
  University Graduate School, Florida International University
• NI
  National Institutes of Health

  Award: R01DA034547