New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD

One of the most significant challenges of inflammatory bowel disease (IBD) research is to understand how alterations in the symbiotic relationship between the genetic composition of the host and the intestinal microbiota, under impact of specific environmental factors, lead to chronic intestinal inflammation. Genome-wide association studies, followed by functional studies, have identified a role for numerous autophagy genes in IBD, especially in Crohn disease. Studies using in vitro and in vivo models, in addition to human clinical studies have revealed that autophagy is pivotal for intestinal homeostasis maintenance, gut ecology regulation, appropriate intestinal immune responses and anti-microbial…

• EC
  European Commission

  Award: 16-IDEX-0001
• AN
  Agence Nationale de la Recherche

  Awards: CAP 20-25, 16-IDEX-0001 CAP 20-25, 16-IDEX-0001
• IN
  Institut National de la Santé et de la Recherche Médicale

  Awards: 16-IDEX-0001, UMR1071, CAP 20-25
• IN
  Institut National de la Recherche Agronomique

  Award: CAP 20-25
• FP
  FP7 People: Marie-Curie Actions