Evolving concepts in bone infection: redefining “biofilm”, “acute vs. chronic osteomyelitis”, “the immune proteome” and “local antibiotic therapy”

Abstract Osteomyelitis is a devastating disease caused by microbial infection of bone. While the frequency of infection following elective orthopedic surgery is low, rates of reinfection are disturbingly high. Staphylococcus aureus is responsible for the majority of chronic osteomyelitis cases and is often considered to be incurable due to bacterial persistence deep within bone. Unfortunately, there is no consensus on clinical classifications of osteomyelitis and the ensuing treatment algorithm. Given the high patient morbidity, mortality, and economic burden caused by osteomyelitis, it is important to elucidate mechanisms of bone infection to inform novel strategies for prevention and curative treatment.…

• BS
  Bristol-Myers Squibb
• UO
  University of Rochester
• AK
  Asahi Kasei Pharma Corporation
• AF
  AO Foundation
• AP
  Astellas Pharma
• NI
  National Institutes of Health

  Awards: AR069655, R01 AG049994, P50 AR072000, P30 AR069655, AR072000, AR061307, P30 AR061307, AR43510
• MC
  Medical Center, University of Rochester
• NI
  National Institute of Arthritis and Musculoskeletal and Skin Diseases

  Awards: P30 AR069655-01 Pilot, AR061307, R21 AR073321, P30 AR069655, AR072000, T32 AR53459, R21 AR074571, AR069655, P30 AR061307, P50 AR072000, R01 AR43510, R01 AI119646, R21 AR500710, R01 AG049994, AR43510