Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

And the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED) and conduct a genome-wide association study of 16,992 cases of anorexia nervosa and 55,525 controls, identifying eight significant loci. The genetic architecture of anorexia nervosa mirrors its clinical presentation, showing significant genetic correlations with psychiatric disorders, physical activity, and metabolic (including glycemic), lipid and anthropometric traits, independent of the effects of common variants associated with body-mass index. These results further encourage a reconceptualization of anorexia nervosa as a metabo-psychiatric disorder. Elucidating the metabolic component is a critical direction for future…

• BS
  Bristol-Myers Squibb
• EL
  Eli Lilly and Company
• P
  Pfizer
• A
  AstraZeneca
• G
  GlaxoSmithKline
• S
  Sanofi
• CH
  Children's Hospital of Philadelphia
• LA
  Louis and Harold Price Foundation
• S
  Sunovion
• WT
  Wellcome Trust
• MC
  Maudsley Charity

  Award: TR130505
• AF
  Academy for Eating Disorders
• AD
  Auckland District Health Board
• FO
  Foundation of Hope for Research and Treatment of Mental Illness
• NI
  National Institute for Health and Care Research
• DO
  Department of Health and Social Care
• KC
  King's College London
• FU
  Flinders University
• CU
  Curtin University of Technology
• L
  Lundbeckfonden
• S
  Shire
• NA
  National and Kapodistrian University of Athens
• GP
  Genesis Pharma
• HL
  H. Lundbeck A/S
• WS
  Western Sydney University
• NI
  National Institutes of Health

  Award: U01MH109528
• NB
  NIHR BioResource
• MR
  Medical Research Council

  Award: 1668713
• NH
  National Health and Medical Research Council

  Award: 310667
• NI
  National Institute of Mental Health

  Awards: U01MH109514, U01MH109528
• NC
  North Carolina Translational and Clinical Sciences Institute, University of North Carolina at Chapel Hill