Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis

Yoshida, Masahiro; Minagawa, Shunsuke; Araya, Jun; Sakamoto, Taro; Hara, Hiromichi; Tsubouchi, Kazuya; Hosaka, Yusuke; Ichikawa, Akihiro; Saito, Nayuta; Kadota, Tsukasa; Sato, Nahoko; Kurita, Yusuke; Kobayashi, Kenji; Ito, Saburo; Utsumi, Hirohumi; Wakui, Hiroshi; Numata, Takanori; Kaneko, Yumi; Mori, Shohei; Asano, Hisatoshi; Yamashita, Makoto; Odaka, Makoto; Morikawa, Toshiaki; Nakayama, Katsutoshi; Iwamoto, Takeo; Imai, Hirotaka; Kuwano, Kazuyoshi

doi:10.1038/s41467-019-10991-7

articleNature CommunicationsJul 17, 2019GOLD OA

Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis

MYMasahiro Yoshida SMShunsuke Minagawa JAJun Araya TSTaro Sakamoto HHHiromichi Hara

Jikei University School of Medicine · Kitasato University

PubMed

Indexed incrossrefdoajpubmed

Abstract

Ferroptosis is a necrotic form of regulated cell death (RCD) mediated by phospholipid peroxidation in association with free iron-mediated Fenton reactions. Disrupted iron homeostasis resulting in excessive oxidative stress has been implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD). Here, we demonstrate the involvement of ferroptosis in COPD pathogenesis. Our in vivo and in vitro models show labile iron accumulation and enhanced lipid peroxidation with concomitant non-apoptotic cell death during cigarette smoke (CS) exposure, which are negatively regulated by GPx4 activity. Treatment with deferoxamine and ferrostatin-1, in addition to GPx4 knockdown, illuminate the role of…

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565

total citations

FWCI: 35.75
Percentile: 100%
References: 48

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Authors

27

Topics & keywords

Topics

Keywords

GPX4
Pathogenesis
Oxidative stress
Programmed cell death
Lipid peroxidation
Autophagy
Ferritin
Apoptosis

UN Sustainable Development Goals

Good health and well-being

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