Viral hijacking of cellular metabolism

This review discusses the current state of the viral metabolism field and gaps in knowledge that will be important for future studies to investigate. We discuss metabolic rewiring caused by viruses, the influence of oncogenic viruses on host cell metabolism, and the use of viruses as guides to identify critical metabolic nodes for cancer anabolism. We also discuss the need for more mechanistic studies identifying viral proteins responsible for metabolic hijacking and for in vivo studies of viral-induced metabolic rewiring. Improved technologies for detailed metabolic measurements and genetic manipulation will lead to important discoveries over the next decade.

• AC
  American Cancer Society

  Award: RSG-16-111-01-MPC
• SB
  St. Baldrick's Foundation
• NI
  National Institutes of Health

  Awards: GM008042, CA009056, RO1 CA215185-01, T32 CA009056, CA215185-01
• UO
  University of California, Los Angeles

  Awards: T32 CA009056, T32AI060567
• NC
  National Cancer Institute

  Awards: CA009056, T32 CA009056
• NI
  National Institute of General Medical Sciences

  Award: GM008042
• JC
  Jonsson Comprehensive Cancer Center
• CD
  Children's Discovery and Innovation Institute, University of California, Los Angeles