circTP63 functions as a ceRNA to promote lung squamous cell carcinoma progression by upregulating FOXM1

Circular RNAs (circRNAs) are identified as vital regulators in a variety of cancers. However, the role of circRNA in lung squamous cell carcinoma (LUSC) remains largely unknown. Herein, we explore the expression profiles of circRNA and mRNA in 5 paired samples of LUSC. By analyzing the co-expression network of differentially expressed circRNAs and dysregulated mRNAs, we identify that a cell cycle-related circRNA, circTP63, is upregulated in LUSC tissues and its upregulation is correlated with larger tumor size and higher TNM stage in LUSC patients. Elevated circTP63 promotes cell proliferation both in vitro and in vivo. Mechanistically, circTP63 shares miRNA response elements with FOXM1. circTP63 competitively…

• NS
  Natural Science Foundation of Shanghai

  Award: 16ZR1434700
• NN
  National Natural Science Foundation of China

  Awards: 81702838, 81402278, 81772461, 81472175
• SA
  Science and Technology Commission of Shanghai Municipality

  Award: 15411961500
• NK
  National Key Research and Development Program of China

  Award: 2015CB553905