Brain-Derived Neurotrophic Factor: A Key Molecule for Memory in the Healthy and the Pathological Brain
Instituto de Neurología Cognitiva · Favaloro University · +1 more institution
Abstract
Brain Derived Neurotrophic Factor (BDNF) is a key molecule involved in plastic changes related to learning and memory. The expression of BDNF is highly regulated, and can lead to great variability in BDNF levels in healthy subjects. Changes in BDNF expression are associated with both normal and pathological aging and also psychiatric disease, in particular in structures important for memory processes such as the hippocampus and parahippocampal areas. Some interventions like exercise or antidepressant administration enhance the expression of BDNF in normal and pathological conditions. In this review, we will describe studies from rodents and humans to bring together research on how BDNF expression is regulated,…
Citation impact
- FWCI
- 53.07
- Percentile
- 100%
- References
- 444
Authors
4- MMMagdalena Miranda
Instituto de Neurología Cognitiva, Favaloro University, Consejo Nacional de Investigaciones Científicas y Técnicas
- JFJuan Facundo Morici
Instituto de Neurología Cognitiva, Consejo Nacional de Investigaciones Científicas y Técnicas, Favaloro University
- MBMaría Belén Zanoni
Favaloro University, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Neurología Cognitiva
- PBPedro BekinschteinCorresponding
Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Neurología Cognitiva, Favaloro University
Topics & keywords
- Pathological
- Neuroscience
- Brain-derived neurotrophic factor
- Neurotrophic factors
- Hippocampus
- Psychology
- Neurotrophin
- Biomarker
- Good health and well-being