articleNature CommunicationsJul 26, 2019GOLD OA

Targeting photodynamic and photothermal therapy to the endoplasmic reticulum enhances immunogenic cancer cell death

WLWei LiJYJie YangLLLihua LuoMJMengshi JiangBQBing Qin

Zhejiang University

PubMed
Indexed incrossrefdoajpubmed

Abstract

Abstract Immunogenic cell death (ICD)-associated immunogenicity can be evoked through reactive oxygen species (ROS) produced via endoplasmic reticulum (ER) stress. In this study, we generate a double ER-targeting strategy to realize photodynamic therapy (PDT) photothermal therapy (PTT) immunotherapy. This nanosystem consists of ER-targeting pardaxin (FAL) peptides modified-, indocyanine green (ICG) conjugated- hollow gold nanospheres (FAL-ICG-HAuNS), together with an oxygen-delivering hemoglobin (Hb) liposome (FAL-Hb lipo), designed to reverse hypoxia. Compared with non-targeting nanosystems, the ER-targeting naosystem induces robust ER stress and calreticulin (CRT) exposure on the cell surface under…

Citation impact

1,105
total citations
FWCI
39.44
Percentile
100%
References
44
Citations per year

Authors

15

Topics & keywords

Topics
Keywords
  • Endoplasmic reticulum
  • Photothermal therapy
  • Photodynamic therapy
  • Immunogenic cell death
  • Programmed cell death
  • Cancer research
  • Cancer
  • Cell
UN Sustainable Development Goals
  • Good health and well-being
No related works found for this paper.

Funding