reviewTranslational PsychiatryAug 5, 2019GOLD OA

Mechanisms and treatment of late-life depression

GSGeorge S. Alexopoulos

Cornell University

PubMed
Indexed incrossrefdoajpubmed

Abstract

Abstract Depression predisposes to medical illnesses and advances biological aging indicated by shorter telomere length, accelerated brain aging and advanced epigenetic aging. Medical illnesses also increase the risk of late-life depression. The reciprocal relationships of depression with aging-related and disease-related processes have generated pathogenetic hypotheses and provided treatment targets. Targeting risk factors of vascular disease in mid-life is a logical approach in prevention of vascular depression. The depression-executive dysfunction and the vascular depression syndromes have clinical presentations and neuroimaging findings consistent with frontostriatal abnormalities. Dopamine D 2/3 agonists…

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Topics & keywords

Topics
Keywords
  • Late life depression
  • Depression (economics)
  • Dementia
  • Disease
  • Psychology
  • Psychiatry
  • Executive dysfunction
  • Medicine
UN Sustainable Development Goals
  • Good health and well-being
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