reviewPhysiological ReviewsJul 31, 2019Closed access

Fundamental Mechanisms of Regulated Cell Death and Implications for Heart Disease

DPDominic P. Del ReDADulguun AmgalanALAndreas LinkermannQLQinghang LiuRNRichard N. Kitsis

Rutgers, The State University of New Jersey · Albert Einstein College of Medicine · +2 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Twelve regulated cell death programs have been described. We review in detail the basic biology of nine including death receptor-mediated apoptosis, death receptor-mediated necrosis (necroptosis), mitochondrial-mediated apoptosis, mitochondrial-mediated necrosis, autophagy-dependent cell death, ferroptosis, pyroptosis, parthanatos, and immunogenic cell death. This is followed by a dissection of the roles of these cell death programs in the major cardiac syndromes: myocardial infarction and heart failure. The most important conclusion relevant to heart disease is that regulated forms of cardiomyocyte death play important roles in both myocardial infarction with reperfusion (ischemia/reperfusion) and heart…

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Authors

5

Topics & keywords

Topics
Keywords
  • Pyroptosis
  • Necroptosis
  • Programmed cell death
  • Necrosis
  • Biology
  • Ischemia
  • Autophagy
  • Apoptosis
UN Sustainable Development Goals
  • Good health and well-being
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