Chronic lymphocytic leukemia: 2020 update on diagnosis, risk stratification and treatment
University of Cologne · Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases
Abstract
DISEASE OVERVIEW: Chronic lymphocytic leukemia (CLL) is the commonest leukemia in western countries. The disease typically occurs in elderly patients and has a highly variable clinical course. Leukemic transformation is initiated by specific genomic alterations that impair apoptosis of clonal B-cells. DIAGNOSIS: The diagnosis is established by blood counts, blood smears, and immunophenotyping of circulating B-lymphocytes, which identify a clonal B-cell population carrying the CD5 antigen, as well as typical B-cell markers. PROGNOSIS: The two similar clinical staging systems, Rai and Binet, create prognostic information by using results of physical examination and blood counts. Various biological and genetic…
Citation impact
- FWCI
- 41.53
- Percentile
- 100%
- References
- 224
Authors
1Topics & keywords
- Chemoimmunotherapy
- Medicine
- Fludarabine
- Chronic lymphocytic leukemia
- Oncology
- Rituximab
- Internal medicine
- Population