Mesenchymal Stem Cell Migration and Tissue Repair
Chongqing University · Nagoya University
Abstract
Mesenchymal stem cells (MSCs) are multilineage cells with the ability to self-renew and differentiate into a variety of cell types, which play key roles in tissue healing and regenerative medicine. Bone marrow-derived mesenchymal stem cells (BMSCs) are the most frequently used stem cells in cell therapy and tissue engineering. However, it is prerequisite for BMSCs to mobilize from bone marrow and migrate into injured tissues during the healing process, through peripheral circulation. The migration of BMSCs is regulated by mechanical and chemical factors in this trafficking process. In this paper, we review the effects of several main regulatory factors on BMSC migration and its underlying mechanism; discuss…
Citation impact
- FWCI
- 61.59
- Percentile
- 100%
- References
- 103
Authors
6Topics & keywords
- Mesenchymal stem cell
- Paracrine signalling
- Stem cell
- Cell biology
- Tissue engineering
- Regenerative medicine
- Clinical uses of mesenchymal stem cells
- Stem cell transplantation for articular cartilage repair