Gut microbes and metabolites as modulators of blood-brain barrier integrity and brain health
Quadram Institute · University of East Anglia
Abstract
The human gastrointestinal (gut) microbiota comprises diverse and dynamic populations of bacteria, archaea, viruses, fungi, and protozoa, coexisting in a mutualistic relationship with the host. When intestinal homeostasis is perturbed, the function of the gastrointestinal tract and other organ systems, including the brain, can be compromised. The gut microbiota is proposed to contribute to blood-brain barrier disruption and the pathogenesis of neurodegenerative diseases. While progress is being made, a better understanding of interactions between gut microbes and host cells, and the impact these have on signaling from gut to brain is now required. In this review, we summarise current evidence of the impact gut…
Citation impact
- FWCI
- 18.20
- Percentile
- 100%
- References
- 229
Authors
3Topics & keywords
- Biology
- Gut–brain axis
- Gut flora
- Gastrointestinal tract
- Blood–brain barrier
- Brain function
- Neuroscience
- Microbiome