Skeletal muscle: A review of molecular structure and function, in health and disease

Decades of research in skeletal muscle physiology have provided multiscale insights into the structural and functional complexity of this important anatomical tissue, designed to accomplish the task of generating contraction, force and movement. Skeletal muscle can be viewed as a biomechanical device with various interacting components including the autonomic nerves for impulse transmission, vasculature for efficient oxygenation, and embedded regulatory and metabolic machinery for maintaining cellular homeostasis. The "omics" revolution has propelled a new era in muscle research, allowing us to discern minute details of molecular cross-talk required for effective coordination between the myriad interacting…

• NS
  National Science Foundation

  Awards: STC‐0939370, STC-0939370, 0939370
• NI
  National Institutes of Health

  Awards: U19 AI090023, U01 CA198941, U01 CA200147, U01 DK097430, R01 LM012595, R01 HD084633, R01 HL108735, R01 DK109365, R01 HL106579, U2C DK119886