CD40 Agonist Antibodies in Cancer Immunotherapy

CD40 is a cell-surface member of the TNF (tumor necrosis factor) receptor superfamily. Upon activation, CD40 can license dendritic cells to promote antitumor T cell activation and re-educate macrophages to destroy tumor stroma. Numerous agonist CD40 antibodies of varying formulations have been evaluated in the clinic and found to be tolerable and feasible. Administration is associated with mild to moderate (but transient) cytokine release syndrome, readily managed in the outpatient setting. Antitumor activity with or without anti-CTLA4 monoclonal antibody (mAb) therapy has been observed in patients with melanoma, and major tumor regressions have been observed in patients with pancreatic cancer, mesothelioma,…

• PI
  Parker Institute for Cancer Immunotherapy
• NI
  National Institutes of Health

  Awards: CA229803, P01 CA210944, P30 CA016520, CA210944, CA016520, R01 CA229803