Neurobiological links between stress and anxiety

Stress and anxiety have intertwined behavioral and neural underpinnings. These commonalities are critical for understanding each state, as well as their mutual interactions. Grasping the mechanisms underlying this bidirectional relationship will have major clinical implications for managing a wide range of psychopathologies. After briefly defining key concepts for the study of stress and anxiety in pre-clinical models, we present circuit, as well as cellular and molecular mechanisms involved in either or both stress and anxiety. First, we review studies on divergent circuits of the basolateral amygdala (BLA) underlying emotional valence processing and anxiety-like behaviors, and how norepinephrine inputs from…

• BA
  Brain and Behavior Research Foundation
• NA
  National Alliance for Research on Schizophrenia and Depression
• AI
  Alberta Innovates - Health Solutions
• IN
  Institut National de la Santé et de la Recherche Médicale
• AI
  Alberta Innovates
• CR
  Conseil Régional Aquitaine
• NI
  National Institutes of Health