Volumetric Bioprinting of Complex Living‐Tissue Constructs within Seconds
Utrecht University · University Medical Center Utrecht · +2 more institutions
Abstract
Biofabrication technologies, including stereolithography and extrusion-based printing, are revolutionizing the creation of complex engineered tissues. The current paradigm in bioprinting relies on the additive layer-by-layer deposition and assembly of repetitive building blocks, typically cell-laden hydrogel fibers or voxels, single cells, or cellular aggregates. The scalability of these additive manufacturing technologies is limited by their printing velocity, as lengthy biofabrication processes impair cell functionality. Overcoming such limitations, the volumetric bioprinting of clinically relevant sized, anatomically shaped constructs, in a time frame ranging from seconds to tens of seconds is described. An…
Citation impact
- FWCI
- 21.92
- Percentile
- 100%
- References
- 55
Authors
7- PNPaulina Núñez Bernal
Utrecht University, University Medical Center Utrecht
- PDPaul Delrot
École Polytechnique Fédérale de Lausanne
- DLDamien Loterie
École Polytechnique Fédérale de Lausanne
- YLYang Li
Utrecht University, University Medical Center Utrecht
- JMJos Malda
University of Applied Sciences Utrecht, Utrecht University, University Medical Center Utrecht
Topics & keywords
- Biofabrication
- Stereolithography
- Materials science
- Self-healing hydrogels
- 3D printing
- Biomedical engineering
- Tissue engineering
- 3D bioprinting
Funding
- ÉPÉcole Polytechnique Fédérale de LausanneAward: 17‐16
- SNSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungAward: 20B1‐1_184178
- GRGebert Rüf StiftungAward: GRS‐057/18
- RReumaNederland
- I-Innosuisse - Schweizerische Agentur für Innovationsförderung
- EREuropean Research CouncilAwards: 3DJOINT, 647426
- H2Horizon 2020Award: 814444