Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy

Developing biomimetic nanoparticles without loss of the integrity of proteins remains a major challenge in cancer chemotherapy. Here, we develop a biocompatible tumor-cell-exocytosed exosome-biomimetic porous silicon nanoparticles (PSiNPs) as drug carrier for targeted cancer chemotherapy. Exosome-sheathed doxorubicin-loaded PSiNPs (DOX@E-PSiNPs), generated by exocytosis of the endocytosed DOX-loaded PSiNPs from tumor cells, exhibit enhanced tumor accumulation, extravasation from blood vessels and penetration into deep tumor parenchyma following intravenous administration. In addition, DOX@E-PSiNPs, regardless of their origin, possess significant cellular uptake and cytotoxicity in both bulk cancer cells and…

• NN
  National Natural Science Foundation of China

  Awards: IRT13016, 81627901, 81803018, 81773653, 81672937, 2015CB931800, 2018YFA0208900
• HU
  Huazhong University of Science and Technology

  Award: 2018QYTD01
• HI
  Helsinki Institute of Life Science, Helsingin Yliopisto
• NK
  National Key Research and Development Program of China

  Awards: 81773653, IRT13016, 81627901, 2018YFA0208900, 2015CB931800
• PF
  Program for Changjiang Scholars and Innovative Research Team in University

  Award: IRT13016