History and progress of hypotheses and clinical trials for Alzheimer’s disease

Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive memory loss along with neuropsychiatric symptoms and a decline in activities of daily life. Its main pathological features are cerebral atrophy, amyloid plaques, and neurofibrillary tangles in the brains of patients. There are various descriptive hypotheses regarding the causes of AD, including the cholinergic hypothesis, amyloid hypothesis, tau propagation hypothesis, mitochondrial cascade hypothesis, calcium homeostasis hypothesis, neurovascular hypothesis, inflammatory hypothesis, metal ion hypothesis, and lymphatic system hypothesis. However, the ultimate etiology of AD remains obscure. In this review, we discuss the main…

• NN
  National Natural Science Foundation of China

  Award: 31171369
• CA
  Chinese Academy of Sciences
• ZU
  Zhengzhou University
• FA
  First Affiliated Hospital of Zhengzhou University
• NK
  National Key Research and Development Program of China

  Award: 2010CB912001