Ambient Particulate Air Pollution and Daily Mortality in 652 Cities

The systematic evaluation of the results of time-series studies of air pollution is challenged by differences in model specification and publication bias.

) with daily all-cause, cardiovascular, and respiratory mortality across multiple countries or regions. Daily data on mortality and air pollution were collected from 652 cities in 24 countries or regions. We used overdispersed generalized additive models with random-effects meta-analysis to investigate the associations. Two-pollutant models were fitted to test the robustness of the associations. Concentration-response curves from each city were pooled to allow global estimates to be derived.