Metabolomics for Investigating Physiological and Pathophysiological Processes

Metabolomics uses advanced analytical chemistry techniques to enable the high-throughput characterization of metabolites from cells, organs, tissues, or biofluids. The rapid growth in metabolomics is leading to a renewed interest in metabolism and the role that small molecule metabolites play in many biological processes. As a result, traditional views of metabolites as being simply the "bricks and mortar" of cells or just the fuel for cellular energetics are being upended. Indeed, metabolites appear to have much more varied and far more important roles as signaling molecules, immune modulators, endogenous toxins, and environmental sensors. This review explores how metabolomics is yielding important new…

• GC
  Genome Canada
• CF
  Canada Foundation for Innovation
• GA
  Genome Alberta
• DF
  Directorate for Biological Sciences
• CI
  Canadian Institutes of Health Research
• NS
  Natural Sciences and Engineering Research Council of Canada