New Insights into Mechanisms of Cisplatin Resistance: From Tumor Cell to Microenvironment
National Health Research Institutes · National Cheng Kung University Hospital
Abstract
Although cisplatin has been a pivotal chemotherapy drug in treating patients with various types of cancer for decades, drug resistance has been a major clinical impediment. In general, cisplatin exerts cytotoxic effects in tumor cells mainly through the generation of DNA-platinum adducts and subsequent DNA damage response. Accordingly, considerable effort has been devoted to clarify the resistance mechanisms inside tumor cells, such as decreased drug accumulation, enhanced detoxification activity, promotion of DNA repair capacity, and inactivated cell death signaling. However, recent advances in high-throughput techniques, cell culture platforms, animal models, and analytic methods have also demonstrated that…
Citation impact
- FWCI
- 18.55
- Percentile
- 100%
- References
- 120
Authors
2Topics & keywords
- Cisplatin
- Tumor microenvironment
- Cancer research
- Drug resistance
- DNA damage
- Angiogenesis
- Biology
- Chemotherapy
- Good health and well-being