Transfer of a healthy microbiota reduces amyloid and tau pathology in an Alzheimer’s disease animal model

Objective Cerebral amyloidosis and severe tauopathy in the brain are key pathological features of Alzheimer’s disease (AD). Despite a strong influence of the intestinal microbiota on AD, the causal relationship between the gut microbiota and AD pathophysiology is still elusive. Design Using a recently developed AD-like pathology with amyloid and neurofibrillary tangles (ADLP APT ) transgenic mouse model of AD, which shows amyloid plaques, neurofibrillary tangles and reactive gliosis in their brains along with memory deficits, we examined the impact of the gut microbiota on AD pathogenesis. Results Composition of the gut microbiota in ADLP APT mice differed from that of healthy wild-type (WT) mice. Besides,…

• NR
  National Research Foundation of Korea

  Awards: 2014M3C7A1046047, 2015M3C9A2054299, 2018R1A5A2025964, 2016R1E1A1A02921587, 2015M3C7A1028790, 2018R1A2A1A19019062, 2018R1A5A1025077, 2017R1A4A1015745, 2017R1A6A3A01004073