Cancer-associated fibroblasts: an emerging target of anti-cancer immunotherapy
Nanjing Medical University · Jiangsu Cancer Hospital · +2 more institutions
Abstract
Among all the stromal cells that present in the tumor microenvironment, cancer-associated fibroblasts (CAFs) are one of the most abundant and critical components of the tumor mesenchyme, which not only provide physical support for tumor cells but also play a key role in promoting and retarding tumorigenesis in a context-dependent manner. CAFs have also been involved in the modulation of many components of the immune system, and recent studies have revealed their roles in immune evasion and poor responses to cancer immunotherapy. In this review, we describe our current understanding of the tumorigenic significance, origin, and heterogeneity of CAFs, as well as the roles of different CAFs subtypes in distinct…
Citation impact
- FWCI
- 40.34
- Percentile
- 100%
- References
- 142
Authors
7- TLTongyan LiuCorresponding
Nanjing Medical University, Jiangsu Cancer Hospital
- CHChencheng Han
Second Affiliated Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Nanjing Medical University
- SWSiwei Wang
Jiangsu Cancer Hospital, Nanjing Medical University, Second Affiliated Hospital of Nanjing Medical University
- PFPanqi Fang
Jiangsu Cancer Hospital, China Pharmaceutical University, Nanjing Medical University
- ZMZhifei Ma
Jiangsu Cancer Hospital, Second Affiliated Hospital of Nanjing Medical University, Nanjing Medical University
Topics & keywords
- Cancer-Associated Fibroblasts
- Immune system
- Tumor microenvironment
- Stromal cell
- Immunotherapy
- Cancer immunotherapy
- Cancer research
- Cancer
- No poverty