The Microbiota-Gut-Brain Axis
University College Cork · APC Microbiome Institute
Abstract
The importance of the gut-brain axis in maintaining homeostasis has long been appreciated. However, the past 15 yr have seen the emergence of the microbiota (the trillions of microorganisms within and on our bodies) as one of the key regulators of gut-brain function and has led to the appreciation of the importance of a distinct microbiota-gut-brain axis. This axis is gaining ever more traction in fields investigating the biological and physiological basis of psychiatric, neurodevelopmental, age-related, and neurodegenerative disorders. The microbiota and the brain communicate with each other via various routes including the immune system, tryptophan metabolism, the vagus nerve and the enteric nervous system,…
Citation impact
- FWCI
- 133.12
- Percentile
- 100%
- References
- 1,676
Authors
33- JFJohn F. CryanCorresponding
University College Cork, APC Microbiome Institute
- KJKenneth J. O’Riordan
University College Cork, APC Microbiome Institute
- CSCaitlin S.M. Cowan
University College Cork, APC Microbiome Institute
- KVKiran V. Sandhu
University College Cork, APC Microbiome Institute
- TFThomaz F. S. Bastiaanssen
University College Cork, APC Microbiome Institute
Topics & keywords
- Gut–brain axis
- Gut flora
- Neuroscience
- Biology
- Microbiome
- Immune system
- Disease
- Autism
- Zero hunger