Reaction-Based Fluorescent Probes for the Detection and Imaging of Reactive Oxygen, Nitrogen, and Sulfur Species

Wu, Luling; Sedgwick, Adam C.; Sun, Xiaolong; Bull, Steven D.; He, Xiao‐Peng; James, Tony D.

doi:10.1021/acs.accounts.9b00302

reviewAccounts of Chemical ResearchAug 28, 2019HYBRID OA

Reaction-Based Fluorescent Probes for the Detection and Imaging of Reactive Oxygen, Nitrogen, and Sulfur Species

LWLuling Wu ACAdam C. Sedgwick XSXiaolong Sun SDSteven D. Bull XHXiao‐Peng He

University of Bath · The University of Texas at Austin · +2 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

This Account describes a range of strategies for the development of fluorescent probes for detecting reactive oxygen species (ROS), reactive nitrogen species (RNS), and reactive (redox-active) sulfur species (RSS). Many ROS/RNS have been implicated in pathological processes such as Alzheimer's disease, cancer, diabetes mellitus, cardiovascular disease, and aging, while many RSS play important roles in maintaining redox homeostasis, serving as antioxidants and acting as free radical scavengers. Fluorescence-based systems have emerged as one of the best ways to monitor the concentrations and locations of these often very short lived species. Because of the high levels of sensitivity and in particular their…

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Topics & keywords

Topics

Keywords

Reactive oxygen species
Fluorescence
Chemistry
Reactive nitrogen species
Redox
Förster resonance energy transfer
Oxidative stress
Photochemistry

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