articleProceedings of the National Academy of SciencesAug 26, 2019BRONZE OA

Gold nanoshell-localized photothermal ablation of prostate tumors in a clinical pilot device study

ARArdeshir R. RastinehadHAHarry AnastosEWEthan WajswolJSJared S. WinokerJPJohn P. Sfakianos

Icahn School of Medicine at Mount Sinai · Nanospectra Biosciences (United States) · +4 more institutions

PubMed
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Abstract

Biocompatible gold nanoparticles designed to absorb light at wavelengths of high tissue transparency have been of particular interest for biomedical applications. The ability of such nanoparticles to convert absorbed near-infrared light to heat and induce highly localized hyperthermia has been shown to be highly effective for photothermal cancer therapy, resulting in cell death and tumor remission in a multitude of preclinical animal models. Here we report the initial results of a clinical trial in which laser-excited gold-silica nanoshells (GSNs) were used in combination with magnetic resonance-ultrasound fusion imaging to focally ablate low-intermediate-grade tumors within the prostate. The overall goal is…

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870
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Authors

16

Topics & keywords

Topics
Keywords
  • Nanoshell
  • Photothermal therapy
  • Materials science
  • Ablation
  • Prostate
  • Tumor ablation
  • Prostate cancer
  • Biomedical engineering
UN Sustainable Development Goals
  • Good health and well-being
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