reviewNutrientsSep 4, 2019GOLD OA

Selenium, Selenoproteins and Viral Infection

OGOlivia GuillinCVCaroline VindryTOThéophile OhlmannLCLaurent Chavatte

Université Claude Bernard Lyon 1 · École Normale Supérieure de Lyon · +3 more institutions

Indexed incrossrefdoaj

Abstract

Reactive oxygen species (ROS) are frequently produced during viral infections. Generation of these ROS can be both beneficial and detrimental for many cellular functions. When overwhelming the antioxidant defense system, the excess of ROS induces oxidative stress. Viral infections lead to diseases characterized by a broad spectrum of clinical symptoms, with oxidative stress being one of their hallmarks. In many cases, ROS can, in turn, enhance viral replication leading to an amplification loop. Another important parameter for viral replication and pathogenicity is the nutritional status of the host. Viral infection simultaneously increases the demand for micronutrients and causes their loss, which leads to a…

Citation impact

450
total citations
FWCI
42.51
Percentile
100%
References
261
Citations per year

Authors

4

Topics & keywords

Topics
Keywords
  • Selenoprotein
  • Biology
  • Viral replication
  • Selenocysteine
  • Selenium deficiency
  • Thioredoxin
  • Oxidative stress
  • Reactive oxygen species
UN Sustainable Development Goals
  • Zero hunger
No related works found for this paper.

Funding