Relationship between Oxidative Stress, ER Stress, and Inflammation in Type 2 Diabetes: The Battle Continues

Type 2 diabetes (T2D) is a metabolic disorder characterized by hyperglycemia and insulin resistance in which oxidative stress is thought to be a primary cause. Considering that mitochondria are the main source of ROS, we have set out to provide a general overview on how oxidative stress is generated and related to T2D. Enhanced generation of reactive oxygen species (ROS) and oxidative stress occurs in mitochondria as a consequence of an overload of glucose and oxidative phosphorylation. Endoplasmic reticulum (ER) stress plays an important role in oxidative stress, as it is also a source of ROS. The tight interconnection between both organelles through mitochondrial-associated membranes (MAMs) means that the…

• UD
  Universitat de València
• FP
  Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana

  Award: UGP15-193, UGP-15-220, UGP-15-144
• ID
  Instituto de Salud Carlos III

  Award: PI16/1083, PI16/0301, FI17/00144, FI17/00126, CIBERehd CB06/04/0071, CPII16/00037