CircRNAs in cancer metabolism: a review

Altered energy metabolism is a hallmark of tumors aiming at supplying necessary nutrients for tumorigenesis and development. These redirected metabolic pathways associated with carbohydrate, lipid and amino acid are orchestrated not only by carcinogenic proteins but by non-coding RNAs. Among them, circular RNA (circRNA), as a kind of novel identified non-coding RNAs, has become the focus of attention. Through binding with corresponding microRNAs or directly contacting proteins, circRNA plays a primarily important role in regulating cellular metabolism. Herein, we analyze the emerging findings and select circRNAs contributing to mutant glycolysis, lipogenesis and lipolysis, glutam inolysis, and oxidative…

• NN
  National Natural Science Foundation of China

  Awards: 81672896, ZDZX2017ZL-01, BK20161066, 81672071
• GO
  Government of Jiangsu Province

  Award: BE2015666
• NS
  Natural Science Foundation of Jiangsu Province

  Awards: 81672896, BK20171304, CXTDC2016006, BK20161066, BE2015666
• JP
  Jiangsu Provincial Department of Education
• NK
  National Key Research and Development Program of China

  Award: ZDZX2017ZL-01