Free Fatty Acid Receptors in Health and Disease
Kyoto University · Japan Agency for Medical Research and Development · +1 more institution
Abstract
Fatty acids are metabolized and synthesized as energy substrates during biological responses. Long- and medium-chain fatty acids derived mainly from dietary triglycerides, and short-chain fatty acids (SCFAs) produced by gut microbial fermentation of the otherwise indigestible dietary fiber, constitute the major sources of free fatty acids (FFAs) in the metabolic network. Recently, increasing evidence indicates that FFAs serve not only as energy sources but also as natural ligands for a group of orphan G protein-coupled receptors (GPCRs) termed free fatty acid receptors (FFARs), essentially intertwining metabolism and immunity in multiple ways, such as via inflammation regulation and secretion of peptide…
Citation impact
- FWCI
- 50.69
- Percentile
- 100%
- References
- 377
Authors
4- IKIkuo KimuraCorresponding
Kyoto University, Japan Agency for Medical Research and Development, Tokyo University of Agriculture and Technology
- AIAtsuhiko Ichimura
Kyoto University, Japan Agency for Medical Research and Development, Tokyo University of Agriculture and Technology
- RORyuji Ohue‐Kitano
Kyoto University, Japan Agency for Medical Research and Development, Tokyo University of Agriculture and Technology
- MIMiki Igarashi
Kyoto University, Japan Agency for Medical Research and Development, Tokyo University of Agriculture and Technology
Topics & keywords
- Free fatty acid receptor 1
- GPR120
- G protein-coupled receptor
- Biochemistry
- Receptor
- Butyrate
- Fatty acid
- Free fatty acid receptor