reviewJournal of Translational MedicineSep 14, 2019GOLD OA

The role of collagen in cancer: from bench to bedside

SXShuaishuai XuHXHuaxiang XuWWWenquan WangSLShuo LiHLHao Li

Shanghai Medical College of Fudan University · Fudan University Shanghai Cancer Center · +1 more institution

PubMed
Indexed incrossrefdoajpubmed

Abstract

Collagen is the major component of the tumor microenvironment and participates in cancer fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes, transcription factors, signaling pathways and receptors; furthermore, collagen can influence tumor cell behavior through integrins, discoidin domain receptors, tyrosine kinase receptors, and some signaling pathways. Exosomes and microRNAs are closely associated with collagen in cancer. Hypoxia, which is common in collagen-rich conditions, intensifies cancer progression, and other substances in the extracellular matrix, such as fibronectin, hyaluronic acid, laminin, and matrix metalloproteinases, interact with collagen to influence…

Citation impact

746
total citations
FWCI
44.66
Percentile
100%
References
318
Citations per year

Authors

9

Topics & keywords

Topics
Keywords
  • Extracellular matrix
  • Cancer cell
  • Discoidin domain
  • Tumor microenvironment
  • Integrin
  • Cancer research
  • Fibronectin
  • Signal transduction
UN Sustainable Development Goals
  • Good health and well-being
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