Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix

Diffraction (X-ray, neutron and electron) and electron cryo-microscopy are powerful methods to determine three-dimensional macromolecular structures, which are required to understand biological processes and to develop new therapeutics against diseases. The overall structure-solution workflow is similar for these techniques, but nuances exist because the properties of the reduced experimental data are different. Software tools for structure determination should therefore be tailored for each method. Phenix is a comprehensive software package for macromolecular structure determination that handles data from any of these techniques. Tasks performed with Phenix include data-quality assessment, map improvement,…

• UD
  U.S. Department of Energy

  Awards: DE-AC02, DE-AC02-05CH1123., AC02-05CH1123, DE-AC02-05CH1123, DE-AC02-
• WT
  Wellcome Trust

  Awards: Z/17/Z, 209407/Z/17/Z
• EC
  European Commission

  Award: 790122
• AN
  Agence Nationale de la Recherche

  Awards: ANR-10, ANR-10-INBS-05
• FI
  French Infrastructure for Integrated Structural Biology

  Award: ANR-10-INBS-05
• NI
  National Institutes of Health

  Awards: DE-AC02-05CH1123, 1R01GM071939, P01GM063210
• H2
  Horizon 2020

  Award: 790122
• OR
  Oak Ridge National Laboratory
• LB
  Lawrence Berkeley National Laboratory

  Award: DE-AC02-05CH1123