reviewLight Science & ApplicationsSep 17, 2019GOLD OA

Single-photon avalanche diode imagers in biophotonics: review and outlook

École Polytechnique Fédérale de Lausanne · University of Neuchâtel · +1 more institution

PubMed
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Abstract

Single-photon avalanche diode (SPAD) arrays are solid-state detectors that offer imaging capabilities at the level of individual photons, with unparalleled photon counting and time-resolved performance. This fascinating technology has progressed at a very fast pace in the past 15 years, since its inception in standard CMOS technology in 2003. A host of architectures have been investigated, ranging from simpler implementations, based solely on off-chip data processing, to progressively "smarter" sensors including on-chip, or even pixel level, time-stamping and processing capabilities. As the technology has matured, a range of biophotonics applications have been explored, including (endoscopic) FLIM, (multibeam…

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