The Devastating Clinical Consequences of Child Abuse and Neglect: Increased Disease Vulnerability and Poor Treatment Response in Mood Disorders

A large body of evidence has demonstrated that exposure to childhood maltreatment at any stage of development can have long-lasting consequences. It is associated with a marked increase in risk for psychiatric and medical disorders. This review summarizes the literature investigating the effects of childhood maltreatment on disease vulnerability for mood disorders, specifically summarizing cross-sectional and more recent longitudinal studies demonstrating that childhood maltreatment is more prevalent and is associated with increased risk for first mood episode, episode recurrence, greater comorbidities, and increased risk for suicidal ideation and attempts in individuals with mood disorders. It summarizes the…

• BA
  Brain and Behavior Research Foundation
• AF
  American Foundation for Suicide Prevention
• AP
  American Psychiatric Publishing
• C
  Celgene
• S
  Sunovion
• OH
  OPKO Health
• NI
  National Institutes of Health

  Awards: AA-024933, MH117293
• DO
  Department of Mechanical Engineering, University of Texas at Austin
• WC
  Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin
• DM
  Dell Medical School, University of Texas at Austin
• LI
  Laureate Institute for Brain Research, University of Tulsa
• JR
  Janssen Research and Development