Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis

Garikipati, Venkata Naga Srikanth; Verma, Suresh K; Cheng, Zhongjian; Liang, Dongming; Truongcao, May; Cimini, Maria; Yue, Yujia; Huang, Grace; Wang, Chunlin; Benedict, Cindy; Tang, Yan; Mallaredy, Vandana; Ibetti, Jessica; Grisanti, Laurel A.; Schumacher, Sarah M.; Gao, Erhe; Rajan, Sudarsan; Wilusz, Jeremy E.; Goukassian, David A.; Houser, Steven R.; Koch, Walter J.; Kishore, Raj

doi:10.1038/s41467-019-11777-7

articleNature CommunicationsSep 20, 2019GOLD OA

Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis

VNVenkata Naga Srikanth Garikipati SKSuresh K Verma ZCZhongjian Cheng DLDongming Liang MTMay Truongcao

Temple University · University of Alabama at Birmingham · +5 more institutions

PubMed

Indexed incrossrefdoajpubmed

Abstract

Circular RNAs are generated from many protein-coding genes, but their role in cardiovascular health and disease states remains unknown. Here we report identification of circRNA transcripts that are differentially expressed in post myocardial infarction (MI) mouse hearts including circFndc3b which is significantly down-regulated in the post-MI hearts. Notably, the human circFndc3b ortholog is also significantly down-regulated in cardiac tissues of ischemic cardiomyopathy patients. Overexpression of circFndc3b in cardiac endothelial cells increases vascular endothelial growth factor-A expression and enhances their angiogenic activity and reduces cardiomyocytes and endothelial cell apoptosis. Adeno-associated…

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Topics & keywords

Topics

Keywords

Circular RNA
Myocardial infarction
Angiogenesis
microRNA
Neovascularization
Vascular endothelial growth factor
Cancer research
Cell biology

UN Sustainable Development Goals

Good health and well-being

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