CAR exosomes derived from effector CAR-T cells have potent antitumour effects and low toxicity
Shanghai Jiao Tong University · Shanghai Ninth People's Hospital · +1 more institution
Abstract
Genetically engineered T cells expressing a chimeric antigen receptor (CAR) are rapidly emerging a promising new treatment for haematological and non-haematological malignancies. CAR-T therapy can induce rapid and durable clinical responses but is associated with unique acute toxicities. Moreover, CAR-T cells are vulnerable to immunosuppressive mechanisms. Here, we report that CAR-T cells release extracellular vesicles, mostly in the form of exosomes that carry CAR on their surface. The CAR-containing exosomes express a high level of cytotoxic molecules and inhibit tumour growth. Compared with CAR-T cells, CAR exosomes do not express Programmed cell Death protein 1 (PD1), and their antitumour effect cannot be…
Citation impact
- FWCI
- 18.75
- Percentile
- 100%
- References
- 63
Authors
15Topics & keywords
- Microvesicles
- Chimeric antigen receptor
- Cytotoxic T cell
- Cancer research
- In vivo
- Effector
- Cytokine
- Immunotherapy
- Good health and well-being