Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma
Fudan University · Zhongshan Hospital · +11 more institutions
Abstract
We performed the first proteogenomic characterization of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) using paired tumor and adjacent liver tissues from 159 patients. Integrated proteogenomic analyses revealed consistency and discordance among multi-omics, activation status of key signaling pathways, and liver-specific metabolic reprogramming in HBV-related HCC. Proteomic profiling identified three subgroups associated with clinical and molecular attributes including patient survival, tumor thrombus, genetic profile, and the liver-specific proteome. These proteomic subgroups have distinct features in metabolic reprogramming, microenvironment dysregulation, cell proliferation, and potential…
Citation impact
- FWCI
- 53.61
- Percentile
- 100%
- References
- 82
Authors
27- QGQiang Gao
Fudan University, Zhongshan Hospital
- HZHongwen Zhu
Chinese Academy of Sciences, Shanghai Institute of Materia Medica
- LDLiangqing Dong
Fudan University, Zhongshan Hospital
- WSWeiwei Shi
Unimed Medical Institute
- RCRan Chen
Chinese Academy of Sciences, Shanghai Institute of Materia Medica, Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences
Topics & keywords
- Hepatocellular carcinoma
- Biology
- Proteogenomics
- Cancer research
- Proteome
- Proteomics
- Liver cancer
- Hepatitis B virus