Tumor Cell Biodiversity Drives Microenvironmental Reprogramming in Liver Cancer
National Cancer Institute · Center for Cancer Research · +3 more institutions
Abstract
Cellular diversity in tumors is a key factor for therapeutic failures and lethal outcomes of solid malignancies. Here, we determined the single-cell transcriptomic landscape of liver cancer biospecimens from 19 patients. We found varying degrees of heterogeneity in malignant cells within and between tumors and diverse landscapes of tumor microenvironment (TME). Strikingly, tumors with higher transcriptomic diversity were associated with patient's worse overall survival. We found a link between hypoxia-dependent vascular endothelial growth factor expression in tumor diversity and TME polarization. Moreover, T cells from higher heterogeneous tumors showed lower cytolytic activities. Consistent results were found…
Citation impact
- FWCI
- 31.22
- Percentile
- 100%
- References
- 81
Authors
16- LMLichun Ma
National Cancer Institute, Center for Cancer Research
- MOMaria O. Hernandez
Leidos (United States), Frederick National Laboratory for Cancer Research, National Cancer Institute, Center for Cancer Research, Leidos Biomedical Research Inc. (United States)
- YZYongmei Zhao
Leidos (United States), Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc. (United States)
- MMMonika Mehta
Leidos (United States), Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc. (United States)
- BTBao Tran
Leidos (United States), Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc. (United States)
Topics & keywords
- Transcriptome
- Cancer research
- Reprogramming
- Tumor microenvironment
- Biology
- Liver cancer
- Cancer
- Cancer cell
- Life in Land