Evaluating phase separation in live cells: diagnosis, caveats, and functional consequences
California Institute for Regenerative Medicine · University of California, Berkeley · +1 more institution
Abstract
The idea that liquid-liquid phase separation (LLPS) may be a general mechanism by which molecules in the complex cellular milieu may self-organize has generated much excitement and fervor in the cell biology community. While this concept is not new, its rise to preeminence has resulted in renewed interest in the mechanisms that shape and drive diverse cellular self-assembly processes from gene expression to cell division to stress responses. In vitro biochemical data have been instrumental in deriving some of the fundamental principles and molecular grammar by which biological molecules may phase separate, and the molecular basis of these interactions. Definitive evidence is lacking as to whether the same…
Citation impact
- FWCI
- —
- Percentile
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- References
- 106
Authors
4- DTDavid T. McSwiggenCorresponding
California Institute for Regenerative Medicine, University of California, Berkeley
- MMMustafa Mir
University of California, Berkeley
- XDXavier Darzacq
California Institute for Regenerative Medicine, University of California, Berkeley
- RTRobert Tjian
Howard Hughes Medical Institute, University of California, Berkeley
Topics & keywords
- Biology
- Computational biology
- Mechanism (biology)
- In vivo
- Cell biology
- Genetics
- Reduced inequalities