Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis
Wuhan University · Zhongnan Hospital of Wuhan University · +1 more institution
Abstract
Reactive oxygen species- (ROS-) induced lipid peroxidation plays a critical role in cell death including apoptosis, autophagy, and ferroptosis. This fundamental and conserved mechanism is based on an excess of ROS which attacks biomembranes, propagates lipid peroxidation chain reactions, and subsequently induces different types of cell death. A highly evolved sophisticated antioxidant system exists that acts to protect the cells from oxidative damage. In this review, we discussed how ROS propagate lipid peroxidation chain reactions and how the products of lipid peroxidation initiate apoptosis and autophagy in current models. We also discussed the mechanism of lipid peroxidation during ferroptosis, and we…
Citation impact
- FWCI
- 108.32
- Percentile
- 100%
- References
- 147
Authors
8- LJL. Joseph Su
Wuhan University, Zhongnan Hospital of Wuhan University
- JZJiahao Zhang
Wuhan University, Zhongnan Hospital of Wuhan University
- HGHernando Gómez
University of Pittsburgh Medical Center
- RMRaghavan Murugan
University of Pittsburgh Medical Center
- XHXing Hong
Wuhan University, Zhongnan Hospital of Wuhan University
Topics & keywords
- Lipid peroxidation
- Reactive oxygen species
- Autophagy
- GPX4
- Cell biology
- Apoptosis
- Programmed cell death
- Chemistry