International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci
University of California San Diego · VA San Diego Healthcare System · +91 more institutions
Abstract
The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 PTSD cases and 170,000 controls we conduct a genome-wide association study of PTSD. We demonstrate SNP-based heritability estimates of 5-20%, varying by sex. Three genome-wide significant loci are identified, 2 in European and 1 in African-ancestry analyses. Analyses stratified by sex implicate 3 additional loci in men. Along with other novel genes and non-coding RNAs, a Parkinson's disease gene involved in dopamine regulation, PARK2, is associated with PTSD. Finally, we demonstrate that polygenic risk for PTSD is significantly…
Citation impact
- FWCI
- 49.30
- Percentile
- 100%
- References
- 89
Authors
179- CMCaroline M. NievergeltCorresponding
University of California San Diego, VA San Diego Healthcare System
- AXAdam X. Maihofer
University of California San Diego, VA San Diego Healthcare System
- TKTorsten Klengel
Harvard University, McLean Hospital, University of Göttingen
- EGElizabeth G. Atkinson
Broad Institute, Massachusetts General Hospital, Stanley Center for Psychiatric Research
- CCChia‐Yen Chen
Broad Institute, Massachusetts General Hospital, Stanley Center for Psychiatric Research
Topics & keywords
- Genome-wide association study
- Meta-analysis
- Genetics
- Genetic association
- Biology
- Association (psychology)
- Genome
- Computational biology
- Good health and well-being