Challenges and Opportunities for Consistent Classification of Human B Cell and Plasma Cell Populations
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Abstract
The increasingly recognized role of different types of B cells and plasma cells in protective and pathogenic immune responses combined with technological advances have generated a plethora of information regarding the heterogeneity of this human immune compartment. Unfortunately, the lack of a consistent classification of human B cells also creates significant imprecision on the adjudication of different phenotypes to well-defined populations. Additional confusion in the field stems from: the use of non-discriminatory, overlapping markers to define some populations, the extrapolation of mouse concepts to humans, and the assignation of functional significance to populations often defined by insufficient surface…
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Authors
8Topics & keywords
Topics
Keywords
- Confusion
- Identification (biology)
- Normative
- Biology
- Immune system
- Disease
- Cell type
- Computational biology
UN Sustainable Development Goals
- Reduced inequalities
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