reviewThe Journal of Experimental MedicineOct 14, 2019BRONZE OA

Biology and therapeutic potential of interleukin-10

MSMargarida SaraivaPVPaulo VieiraAOAnne O’Garra

Universidade do Porto · i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto · +7 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

The cytokine IL-10 is a key anti-inflammatory mediator ensuring protection of a host from over-exuberant responses to pathogens and microbiota, while playing important roles in other settings as sterile wound healing, autoimmunity, cancer, and homeostasis. Here we discuss our current understanding of the regulation of IL-10 production and of the molecular pathways associated with IL-10 responses. In addition to IL-10's classic inhibitory effects on myeloid cells, we also describe the nonclassic roles attributed to this pleiotropic cytokine, including how IL-10 regulates basic processes of neural and adipose cells and how it promotes CD8 T cell activation, as well as epithelial repair. We further discuss its…

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1,078
total citations
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24.12
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100%
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276
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Authors

3

Topics & keywords

Topics
Keywords
  • Mediator
  • Biology
  • Cytokine
  • Autoimmunity
  • Immunology
  • Context (archaeology)
  • Inflammation
  • Immune system
UN Sustainable Development Goals
  • Good health and well-being
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