reviewAnnual Review of EntomologyOct 14, 2019BRONZE OA

Mechanisms, Applications, and Challenges of Insect RNA Interference

KYKun Yan ZhuSRSubba Reddy Palli

Kansas State University · University of Kentucky

PubMed
Indexed incrossrefpubmed

Abstract

The RNA interference (RNAi) triggered by short/small interfering RNA (siRNA) was discovered in nematodes and found to function in most living organisms. RNAi has been widely used as a research tool to study gene functions and has shown great potential for the development of novel pest management strategies. RNAi is highly efficient and systemic in coleopterans but highly variable or inefficient in many other insects. Differences in double-stranded RNA (dsRNA) degradation, cellular uptake, inter- and intracellular transports, processing of dsRNA to siRNA, and RNA-induced silencing complex formation influence RNAi efficiency. The basic dsRNA delivery methods include microinjection, feeding, and soaking. To…

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656
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Authors

2

Topics & keywords

Topics
Keywords
  • RNA interference
  • RNA silencing
  • Biology
  • RNA
  • Small interfering RNA
  • Gene silencing
  • Trans-acting siRNA
  • Cell biology
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