Six-Month Randomized, Multicenter Trial of Closed-Loop Control in Type 1 Diabetes

Closed-loop systems that automate insulin delivery may improve glycemic outcomes in patients with type 1 diabetes.

In this 6-month randomized, multicenter trial, patients with type 1 diabetes were assigned in a 2:1 ratio to receive treatment with a closed-loop system (closed-loop group) or a sensor-augmented pump (control group). The primary outcome was the percentage of time that the blood glucose level was within the target range of 70 to 180 mg per deciliter (3.9 to 10.0 mmol per liter), as measured by continuous glucose monitoring.