articleScienceSep 26, 2019GREEN OA

Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

NANikolaos A. PatsopoulosSESergio E. BaranziniASAdam SantanielloPSParisa ShoostariCCChris Cotsapas

University of California, San Francisco · Yale University · +9 more institutions

PubMed
Indexed incrossrefdatacitepubmed

Abstract

We analyzed genetic data of 47,429 multiple sclerosis (MS) and 68,374 control subjects and established a reference map of the genetic architecture of MS that includes 200 autosomal susceptibility variants outside the major histocompatibility complex (MHC), one chromosome X variant, and 32 variants within the extended MHC. We used an ensemble of methods to prioritize 551 putative susceptibility genes that implicate multiple innate and adaptive pathways distributed across the cellular components of the immune system. Using expression profiles from purified human microglia, we observed enrichment for MS genes in these brain-resident immune cells, suggesting that these may have a role in targeting an autoimmune…

Citation impact

1,407
total citations
FWCI
53.44
Percentile
100%
References
69
Citations per year

Authors

157

Topics & keywords

Topics
Keywords
  • Multiple sclerosis
  • Immune system
  • Major histocompatibility complex
  • Microglia
  • Biology
  • Gene
  • Immunology
  • Innate immune system
UN Sustainable Development Goals
  • Good health and well-being
No related works found for this paper.

Funding