Reductive Amination in the Synthesis of Pharmaceuticals
A. N. Nesmeyanov Institute of Organoelement Compounds · Broad Institute · +2 more institutions
Abstract
Reductive amination plays a paramount role in pharmaceutical and medicinal chemistry owing to its synthetic merits and the ubiquitous presence of amines among biologically active compounds. It is one of the key approaches to C-N bond construction due to its operational easiness and a wide toolbox of protocols. Recent studies show that at least a quarter of C-N bond-forming reactions in the pharmaceutical industry are performed via reductive amination. This Review concisely compiles information on 71 medical substances that are synthesized by reductive amination. Compounds are grouped according to the principle of action, which includes drugs affecting the central nervous system, drugs affecting the…
Citation impact
- FWCI
- 22.92
- Percentile
- 100%
- References
- 272
Authors
4- OIOleg I. Afanasyev
A. N. Nesmeyanov Institute of Organoelement Compounds
- EAEkaterina A. Kuchuk
A. N. Nesmeyanov Institute of Organoelement Compounds
- DLDmitry L. Usanov
Broad Institute
- DCDenis ChusovCorresponding
National Research University Higher School of Economics, Peoples' Friendship University of Russia, A. N. Nesmeyanov Institute of Organoelement Compounds
Topics & keywords
- Reductive amination
- Chemistry
- Amination
- Combinatorial chemistry
- Organic chemistry
- Catalysis