Theabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism
Shanghai Jiao Tong University · Shanghai Sixth People's Hospital · +8 more institutions
Abstract
Pu-erh tea displays cholesterol-lowering properties, but the underlying mechanism has not been elucidated. Theabrownin is one of the most active and abundant pigments in Pu-erh tea. Here, we show that theabrownin alters the gut microbiota in mice and humans, predominantly suppressing microbes associated with bile-salt hydrolase (BSH) activity. Theabrownin increases the levels of ileal conjugated bile acids (BAs) which, in turn, inhibit the intestinal FXR-FGF15 signaling pathway, resulting in increased hepatic production and fecal excretion of BAs, reduced hepatic cholesterol, and decreased lipogenesis. The inhibition of intestinal FXR-FGF15 signaling is accompanied by increased gene expression of enzymes in…
Citation impact
- FWCI
- 30.71
- Percentile
- 100%
- References
- 46
Authors
27- FHFengjie Huang
Shanghai Jiao Tong University, Shanghai Sixth People's Hospital
- XZXiaojiao Zheng
Shanghai Jiao Tong University, Shanghai Sixth People's Hospital
- XMXiaohui Ma
Tasly Holding Group (China)
- RJR Jiang
University of Hawaiʻi at Mānoa, University of Hawaii System, Cancer Center of Hawaii, University of Hawaii Cancer Center
- WZWangyi Zhou
Tasly Holding Group (China)
Topics & keywords
- Gut flora
- Bile acid
- Chemistry
- Chenodeoxycholic acid
- Lipid metabolism
- Cholesterol
- Lipogenesis
- Metabolism